Dyslipidaemia
1 Familial (primary) dyslipidaemia ● Due to gene mutation(s). ● Should be suspected in patients with premature IHD (age <55 in men, <60 in women). ● WHO classifies them type 1-5 (T1-5). 2 Acquired (secondary) dyslipidaemia Most cases of dyslipidaemia are acquired in later life. Obesity, sedentary lifestyle, and diabetes are common risk factors, though many cases are essentially idiopathic. Other causes: ● Endocrine: hypothyroidism, hypopituitarism. ● Hepatic: alcohol excess, cholestasis. ● Renal: nephrotic syndrome, chronic kidney disease. ● Others: pregnancy, anorexia, gout, antipsychotics. Signs and symptoms Usually detected through CVD risk assessment, or when presenting with complications such as IHD or stroke. The only specific sign is lipid deposits (xanthomas). Their presence and extent are a sign of disease severity. Locations: ● ...