Nephrolithiasis • Calcium oxalate (and to some degree calcium phosphate) stones account for 80% of all kidney stones • Remaining stones are uric acid (10%), struvite (10-15%) and cystine (1%) stones • It is possible for patient to have multiple stones and for them to be more than one type of stone Risk Factors • Crystallization occurs when otherwise soluble solutes precipitate due to supersaturation or changes in urinary pH, protein content, or due to reaction with other solutes • Crystals cause epithelial injury, deposition of stone formation, bleeding, obstruction, and pain • Frequently identified risk factors include hypercalciuria, hyperoxaluria, hypocitraturia, decreased calcium intake, increased oxalate intake, increased animal protein intake, and decreased hydration • There is more than 2-fold increase in risk of kidney stones with positive family hx of kidney stones • Patients with history of kidney stones have a 10-30% 3-5 year recurrence rate • 25% of people with gout will ge...
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